Key result
Among 41 HAV-RNA positive samples from sporadic acute hepatitis A patients in Korea, 60% were identified as subgenotype IIIA and 40% as subgenotype IA, reflecting co-circulation of various genotypes.
Observational (n=46)
No
In sporadic acute hepatitis A cases in Korea, HAV subgenotypes IIIA and IA co-circulate, providing important epidemiological data for public health measures.
May inform regional HAV surveillance; leaves open effects on transmission, severity, and vaccine strategies.
PURPOSE: Hepatitis A virus (HAV) has been a leading cause of acute hepatitis in Korea. The reported genotypes of acute hepatitis A in Korea are the subgenotype IA and IB. The aim of the present study is to investigate HAV genotypes in the south-east area of Gyeonggi-do in Korea. MATERIALS AND METHODS: From June 2004 to June 2006, 46 acute hepatitis A patients were enrolled prospectively. All had sporadic acute hepatitis A patients. All suspected cases of acute hepatitis A were tested for IgM anti-HAV antibodies. We sequenced 168 bp of nucleotides of the putative VP1/P2A junction and determined the HAV genotype with reverse transcriptase polymerase chain reaction. The clinical and laboratory results of all patients were recorded. RESULTS: HAV-ribonucleic acid (RNA) was detected in 41 samples out of 46 samples. Among the 41 samples, 25 (60%) were shown to have subgenotype IIIA and the other 16 (40%) were subgenotype IA. Several amino acid substitutions were found. CONCLUSION: In these HAV sporadic cases, IIIA and IA were identified, and this may reflect co-circulation of various genotypes in Korea. This study provides valuable new data on the genetic distribution of HAV and important information to help design appropriate public health measures.
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Song et al. (2009) conducted an observational in Acute hepatitis A (n=46). Hepatitis A virus infection was evaluated on HAV genotype distribution. Among 41 HAV-RNA positive samples from sporadic acute hepatitis A patients in Korea, 60% were identified as subgenotype IIIA and 40% as subgenotype IA, reflecting co-circulation of various genotypes.
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