Key result
Hepatitis A virus genotype IIIA was the dominant genotype, accounting for 88% of infections compared to 12% for genotype IA (p≤0.01).
Cross-Sectional (n=82)
No
Absolute Event Rate: 88% vs 12%
p-value: p=≤0.01
Genotype IIIA has become the dominant genotype of recent Hepatitis A virus infections in the Gwangju and Jeonnam province of Korea, replacing the previously dominant genotype IA.
May warrant updated regional HAV surveillance in Korea; extends local epidemiology but leaves broader applicability open.
BACKGROUND/AIMS: Dominant genotype of hepatitis A virus (HAV) in Korea had been known to be genotype 1A in 1990s. Recently, the epidemiologic change of HAV genotype was reported with an upsurge of acute hepatitis A in Korea. The aim of this study was to investigate the change of HAV genotypes and clinical characteristics in Gwangju and Jeonnam province. METHODS: From November 2008 to October 2009, a total of 82 patients with acute hepatitis A were enrolled prospectively. HAV genotype was determined using reverse transcriptase polymerase chain reaction and sequencing of the PCR products of VP1/2A region of HAV. RESULTS: HAV RNA was detected in 82% (67/82). The genotype IIIA (88%, 59 cases) was significantly more frequent than genotype IA (12%, 8 cases) (p ≤ 0.01). The subtypes of genotype IIIA were AJ299467 Norway (49%), HA-JNG04-09 Japan (27%), HS-14-12-00 Spain (22%) and H-122 Sweden (2%). The subtypes of IA were FH1 Japan (50%) and HA J04-3 Japan (50%). The substitutions of amino acid were more frequent in genotype IIIA than IA (p≤ 0.01). There was no difference in the clinical characteristics between the patients with genotype IIIA and IA. CONCLUSIONS: Genotype IIIA was a dominant genotype of recent HAV infection in Gwangju and Jeonnam province. This study provides valuable epidemiologic information of genetic distributions of HAV in Korea.
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Noh et al. (2011) conducted a cross-sectional in Acute hepatitis A (n=82). HAV Genotype IIIA vs. HAV Genotype IA was evaluated on Frequency of HAV genotypes (p=≤0.01). Hepatitis A virus genotype IIIA was the dominant genotype, accounting for 88% of infections compared to 12% for genotype IA (p≤0.01).
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