Key result
Genetic analysis of 54 HAV isolates from Korean patients revealed co-circulation of genotypes IA (n=45) and IIIA (n=9), with a prevalent 810Q to S amino acid substitution in 14 isolates.
Population
160 HAV IgM positive sera and 6 stools from an outbreak in Gyeonggi province, Korea, collected during…
Design
Cross-sectional
Authors
Loading...
Warrants updated HAV molecular surveillance in Korea; leaves open whether co-circulation or 810Q>S alters transmissibility or outcomes.
Cross-Sectional (n=166)
The molecular epidemiology of HAV infection in Korea has changed, with co-circulation of at least two genotypes (IA and IIIA) and prevalent amino acid substitutions, suggesting importation from high-endemic countries.
Yun et al. (2008) conducted a cross-sectional in Acute hepatitis A (n=166). HAV infection was evaluated on HAV genotype distribution and amino acid substitutions. Genetic analysis of 54 HAV isolates from Korean patients revealed co-circulation of genotypes IA (n=45) and IIIA (n=9), with a prevalent 810Q to S amino acid substitution in 14 isolates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: