Poliovirus infection does not inhibit the translation of ribosomal protein mRNAs, a process that correlates with increased p70(s6k) activity and S6 phosphorylation.
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No immediate clinical implications; leaves open the role of p70(s6k)-S6 in viral translation resistance.
Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.
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Cardinali et al. (1999) studied this question.
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