Key result
Chronic subcutaneous and intravenous angiotensin II increase blood pressure by different mechanisms, producing distinct physiological and pathological effects in rodent models.
Why the study?
Do intravenous and subcutaneous angiotensin II increase blood pressure by different mechanisms?
Population
Rodents (males and females)
Comparison
Chronic subcutaneous angiotensin II administration vs Chronic intravenous angiotensin II administration
Design
Review
Authors
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Distinct effects by route in rodent models caution against interchangeability; leaves open differential relevance to human hypertension.
Do intravenous and subcutaneous angiotensin II increase blood pressure by different mechanisms?
The different effects of chronic intravenous and subcutaneous AngII suggest these two models of hypertension provide different information and may differ in their relevance to human hypertension.
Duncan J. Campbell (2013) conducted a review in Hypertension. Subcutaneous vs Intravenous Angiotensin II was evaluated. Chronic subcutaneous and intravenous angiotensin II increase blood pressure by different mechanisms, producing distinct physiological and pathological effects in rodent models.
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