Key result
In patients with atrial septal defect and normal resting right ventricular systolic pressure, exercise stress echocardiography revealed latent pulmonary hypertension (RVSP increase from 25.7 to 45.3 mmHg, p<0.001) that was significantly reduced following ASD closure.
Why the study?
Does ASD closure reduce latent pulmonary hypertension and induce right ventricular reverse remodeling in patients with atrial septal defect?
Observational (n=59)
Does ASD closure reduce latent pulmonary hypertension and induce right ventricular reverse remodeling in patients with atrial septal defect?
Absolute Event Rate: 45.3% vs 25.7%
p-value: p=<0.001
Exercise stress echocardiography can unmask latent pulmonary hypertension in ASD patients, which significantly improves along with right ventricular reverse remodeling after ASD closure.
No takes yet. Share an insight, caveat, or question.
Exercise echocardiography may unmask latent PH in ASD; leaves open whether closure improves outcomes in randomized trials.
Lange et al. (2013) conducted an observational in Atrial septal defect (n=59). Exercise stress echocardiography and ASD closure vs. Rest / Baseline pre-closure was evaluated on Right ventricular systolic pressure (RVSP) during exercise stress echocardiography in patients with normal resting RVSP (p=<0.001). In patients with atrial septal defect and normal resting right ventricular systolic pressure, exercise stress echocardiography revealed latent pulmonary hypertension (RVSP increase from 25.7 to 45.3 mmHg, p<0.001) that was significantly reduced following ASD closure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: