What question did this study set out to answer?

To determine whether cerebral vasculature contributes to the elevated plasma levels of adrenomedullin observed during and after cardiopulmonary bypass.

May 1, 1999Anesthesia & Analgesia

Cerebral Production of Adrenomedullin After Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgical Patients

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Authors

SISatoki InoueFukushima Medical University YHYukio HayashiTaiho Pharmaceutical (Japan)YOYoshihiko OhnishiNational Cerebral and Cardiovascular Center

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Implication

Prospective study reveals increased cerebral adrenomedullin production after cardiopulmonary bypass in cardiac surgery patients, indicating brain vasculature contributes to circulating levels.

Key Points

To determine whether cerebral vasculature contributes to the elevated plasma levels of adrenomedullin observed during and after cardiopulmonary bypass.
Evaluated 10 patients undergoing coronary artery bypass grafting with mild hypothermic cardiopulmonary bypass.
Measured cerebral blood flow before, during, and after bypass using the Kety-Schmidt method.
Analyzed paired plasma adrenomedullin concentrations from the radial artery and internal jugular bulb using radioimmunoassay to calculate cerebral production.
Adrenomedullin production within the cerebral vasculature increased significantly after cardiopulmonary bypass compared with pre-bypass values.
Post-bypass cerebral adrenomedullin production correlated significantly with aortic cross-clamping time.

Cite This Study

Inoue et al. (1999) studied this question.

synapsesocial.com/papers/6a8451e49c756a6796f2f475 https://doi.org/10.1097/00000539-199905000-00011

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Implication

Prospective study reveals increased cerebral adrenomedullin production after cardiopulmonary bypass in cardiac surgery patients, indicating brain vasculature contributes to circulating levels.

Cerebral Production of Adrenomedullin After Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgical Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebral Production of Adrenomedullin After Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgical Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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