July 1, 1982Circulation
Neuronal and adrenomedullary catecholamine release in response to cardiopulmonary bypass in man.
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Discussion
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Implication
Clinical study demonstrates a ninefold surge in epinephrine during cardiopulmonary bypass in surgical patients, suggesting adrenomedullary activation may jeopardize myocardial protection.
Key Points
- To evaluate changes in circulating epinephrine and norepinephrine levels at distinct surgical stages during cardiopulmonary bypass.
- Measured plasma epinephrine and norepinephrine using radioenzymatic assays across eight surgical stages in 28 patients undergoing operations with cardiopulmonary bypass (N=28).
- Arterial epinephrine increased ninefold from prebypass baseline (75 ± 13 pg/ml) to the end of aortic cross-clamping (708 ± 117.3 pg/ml, p < 0.05 vs all other stages) before declining to 360 ± 84.3 pg/ml after reperfusion.
- Arterial norepinephrine increased twofold from baseline to the end of cross-clamping (from 426 ± 66.9 pg/ml to 825 ± 84.2 pg/ml, p < 0.05), and early bypass increases correlated with mean blood pressure (r = 0.51, p = 0.02).
Cite This Study
Rêves et al. (1982) studied this question.