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February 1, 1980Acta Anaesthesiologica Scandinavica

Sympathetic Nervous System Tonicity and Post‐Coronary Artery Bypass Hypertension

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Why the study?

Does plasma catecholamine concentration correlate with the development of hypertension following coronary bypass surgery in patients with coronary artery disease?

Population

28 patients with coronary artery disease undergoing myocardial revascularization procedures

Comparison

Myocardial revascularization procedures vs Patients who remained normotensive after surgery…

Design

Cohort

Follow-up

4 hours after surgery

Authors

VPVasilios PratilasMount Sinai Beth IsraelMPM. G. PratijaIcahn School of Medicine at Mount SinaiNVN. D. VlachakisUniversity of Southern California

Discussion

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Implication

Post-CABG norepinephrine rise may flag hypertension risk; hypothesis-generating and requires prospective trials before practice change.

Structured PICO

Does plasma catecholamine concentration correlate with the development of hypertension following coronary bypass surgery in patients with coronary artery disease?

P
Population
28 patients with coronary artery disease undergoing myocardial revascularization procedures (coronary bypass surgery)
I
Intervention
Myocardial revascularization procedures (coronary bypass surgery)
C
Comparator
Patients who remained normotensive after surgery vs those who developed hypertension
O
Outcome
Blood pressure and plasma catecholamine concentration (norepinephrine and epinephrine) at 1 and 4 hours after surgerysurrogate

Coronary bypass surgery acts as a potent adrenergic stimulus, with early postoperative increases in plasma norepinephrine correlating with the development of hypertension.

Cite This Study

Pratilas et al. (1980) studied this question.

synapsesocial.com/papers/6a20b9c3300c028f6f397648https://doi.org/10.1111/j.1399-6576.1980.tb01508.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Plasma Catecholamine Increases During Surgical Stress in Man1977 · 285 citations
  2. 2Circulating catecholamine levels in human and experimental hypertension.1976 · 357 citations
  3. 3Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs1965 · 349 citations
  4. 4Effects of Catecholamines and Renal Nerve Stimulation on Renin Release in the Nonfilterlng Kidney1971 · 126 citations
  5. 5Control of renin secretion in the anesthetized dog1964 · 326 citations