Population
Isolated preparations of rat caudal artery, guinea-pig atria, and pithed rats
Comparison
Tetradecapeptide renin substrate vs Baseline/control conditions, with or without…
Design
Preclinical
Authors
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Animal data support local angiotensin II enhancement of sympathetic responses; leaves open relevance to human cardiovascular disease.
Tetradecapeptide renin substrate facilitates noradrenergic transmission via angiotensin II receptors in isolated tissues, while its pressor effect in vivo is partially dependent on converting enzyme activity.
Ziogas et al. (1986) studied this question.
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