Why the study?
Does porcine tetradecapeptide renin substrate induce contraction in human resistance vessels via enzymes specific to the renin-angiotensin cascade?
Population
Human resistance vessels from skin and subcutaneous fat mounted in a myograph
Comparison
Porcine tetradecapeptide renin substrate in the… vs TDP in the absence of inhibitors
Design
Preclinical
Authors
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TDP-induced contraction may involve non-classical enzymes in human vessels; leaves open whether classical RAS blockade fully accounts for vascular tone.
Does porcine tetradecapeptide renin substrate induce contraction in human resistance vessels via enzymes specific to the renin-angiotensin cascade?
Porcine tetradecapeptide renin substrate induces contraction in human resistance vessels through enzymes not specific to the classical renin-angiotensin cascade.
Bund et al. (1989) studied this question.
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