What is the clinical evidence from this study?

Study design: Other. Intervention: Tyrosine kinase inhibitors (genistein and tyrphostin). Primary outcome: Inhibition of contractile actions of vascular agonists.

September 1, 1994Canadian Journal of Physiology and Pharmacology

Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists

Q: What does this research mean for the field?

The tyrosine kinase inhibitors genistein and tyrphostin selectively inhibit the contractile action of specific G-protein-linked vascular agonists in porcine and rat arterial tissues. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Genistein and tyrphostin selectively inhibit G-protein-linked vascular agonist contraction in porcine and rat arteries.

Population

Porcine coronary artery and rat aorta helical strip preparations

Design

Preclinical

Authors

ALAdebayo LaniyonuUnited States Food and Drug Administration MSM SaifeddineUniversity of Calgary SYSong‐Gui YangTulane University

Discussion

Member takes

Implication

Implicates nonreceptor tyrosine kinases in G-protein-mediated vasoconstriction; leaves open relevance to human vascular disease.

Structured PICO

Population

Porcine coronary artery and rat aorta helical strip preparations

Intervention

Tyrosine kinase inhibitors (genistein and tyrphostin [AG82])

Outcome

Contractile actions of G-protein-linked vascular agonists and phosphotyrosyl protein content/tyrosine kinase activitysurrogate

Selected G-protein-linked contractile vascular agonists may act in part via the stimulation of nonreceptor tyrosine kinases in arterial preparations.

Cite This Study

Laniyonu et al. (1994) studied this question. Tyrosine kinase inhibitors (genistein and tyrphostin) was evaluated on Inhibition of contractile actions of vascular agonists. Genistein and tyrphostin selectively inhibited the contractile action of specific G-protein-linked vascular agonists in porcine and rat arterial preparations.

synapsesocial.com/papers/6aa6c0822e0c4dc4f87f44f8 https://doi.org/10.1139/y94-150

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Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider