February 1, 2001HypertensionOpen Access

Tyrosine Kinase Involvement in Renal Arteriolar Constrictor Responses to Angiotensin II

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Population

Rats subjected to short-term enalaprilat treatment and acute surgical papillectomy, using the in vitro…

Comparison

Tyrphostin compounds: 100 micromol/L AG18 or 100… vs Untreated conditions or 100 micromol/L AG9

Design

Preclinical

Authors

PCPamela K. CarminesUniversity of Nebraska Medical Center RFRachel W. FalletUniversity of Nebraska Medical Center QCQi CheFudan University

Discussion

Member takes

Implication

Should not change hypertension management; hypothesis-generating for EGFR tyrosine kinase modulation of Ang II renal arteriolar tone.

Structured PICO

Population

Rats subjected to short-term enalaprilat treatment and acute surgical papillectomy, using the in vitro blood-perfused juxtamedullary nephron technique

Intervention

Tyrphostin compounds: 100 micromol/L AG18 (broad-spectrum tyrosine kinase inhibitor) or 100 nmol/L AG1478 (selective epidermal growth factor receptor tyrosine kinase inhibitor) before and during Angiotensin II (1 and 10 nmol/L) exposure

Comparator

Untreated conditions (Ang II alone) or 100 micromol/L AG9 (inactive analog)

Outcome

Arteriolar lumen diameter responses (afferent and efferent)surrogate

Tyrosine kinase activity, including EGFR tyrosine kinase, mediates or modulates Angiotensin II signaling in renal afferent and efferent arteriolar vascular smooth muscle.

Cite This Study

Carmines et al. (2001) studied this question.

synapsesocial.com/papers/6a71424bf44fa9f079df0b15 https://doi.org/10.1161/01.hyp.37.2.569

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Tyrosine Kinase Involvement in Renal Arteriolar Constrictor Responses to Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tyrosine Kinase Involvement in Renal Arteriolar Constrictor Responses to Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider