September 1, 2001Journal of the Renin-Angiotensin-Aldosterone System

Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity

View Full Paper

Ask AI

Bookmark

Population

Rat aorta smooth muscle

Comparison

Genistein, daidzein, and nifedipine vs Control (no inhibitor) or daidzein

Design

Preclinical

Authors

GPG PetrescuCarol Davila University of Medicine and Pharmacy MCMarcel CostuleanuGrigore T. Popa University of Medicine and Pharmacy SSSimona Mihaela SlătineanuGrigore T. Popa University of Medicine and Pharmacy

Discussion

Member takes

Implication

Findings in rat aorta are hypothesis-generating; leaves open translation to human angiotensin signaling or therapy.

Structured PICO

Population

Rat aorta smooth muscle

Intervention

Genistein (tyrosine-kinase inhibitor), daidzein (inactive analogue), and nifedipine (L-type Ca2+ channel blocker)

Comparator

Control (no inhibitor) or daidzein

Outcome

Contractile effects induced by angiotensin peptides (Ang I, Ang II, Ang III, Ang IV)surrogate

Angiotensin IV and III-induced contractions in rat aorta are more dependent on tyrosine kinase activity and calcium influx than those evoked by Ang II or Ang I.

Cite This Study

Petrescu et al. (2001) studied this question.

synapsesocial.com/papers/6a894057b4e829b19bd43c44 https://doi.org/10.3317/jraas.2001.025

View Full Paper

Ask AI

Bookmark

Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider