Key result
Perivascular adipose tissue acts as an endocrine organ releasing relaxing and contracting factors that influence vascular homeostasis and contribute to cardiovascular diseases.
Why the study?
Once viewed solely as structural support, perivascular adipose tissue is now recognized as an endocrine organ whose expansion and dysfunction contribute to cardiovascular homeostasis and disease.
Answers are grounded in this paper and cite their sources.
This review highlights the emerging role of perivascular adipose tissue as an endocrine organ that influences vascular homeostasis and cardiovascular disease.
Perivascular adipose tissue (PVAT) had long been considered to serve only structural, vessel-supporting purposes, but today PVAT is recognized to be an endocrine organ with important physiological and pathological effects. The expansion of PVAT in vascular homeostasis and vascular disease has attracted much interest. PVAT has been shown to release a wide spectrum of molecules, such as PVAT-derived relaxing factors (PVATRFs) and PVAT-derived contracting factors (PVATCFs). PVAT dysfunction may lead to obesity, atherosclerosis, and other cardiovascular diseases. This review describes recent advances in our understanding of PVAT's important effects on the cardiovascular system.
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A 2020 study conducted a review in Cardiovascular diseases. Perivascular adipose tissue (PVAT) was evaluated. Perivascular adipose tissue acts as an endocrine organ releasing relaxing and contracting factors that influence vascular homeostasis and contribute to cardiovascular diseases.
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