Key result
The +45T>G SNP in ADIPOQ was associated with reduced odds of the metabolically unhealthy phenotype in normal-weight subjects, and the GG haplotype was linked to lower serum adiponectin levels.
Why the study?
Not all individuals with excess weight show metabolic alterations and not all normal-weight individuals have a metabolically healthy phenotype, likely due to gene-environment interactions.
Are ADIPOQ and PPARG genetic variants associated with metabolic phenotypes and serum adiponectin levels in normal-weight and excess-weight adults?
Cross-Sectional (n=345)
Are ADIPOQ and PPARG genetic variants associated with metabolic phenotypes and serum adiponectin levels in normal-weight and excess-weight adults?
ADIPOQ genetic variants, specifically the +45T>G SNP, and lower serum adiponectin levels are associated with a metabolically unhealthy phenotype, particularly in individuals with excess weight.
ADIPOQ variants may mark metabolic risk in normal-weight adults; hypothesis-generating and should not yet change practice.
BACKGROUND: Even though excessive adipose tissue is related to chronic metabolic disturbances, not all subjects with excess weight (EW) display metabolic alterations, and not all normal-weight (NW) subjects have a metabolically healthy (MH) phenotype, probably due to gene-environment interactions. The aim of this study was to investigate the interaction effects of ADIPOQ and PPARG genetic variants in NW and EW individuals with different metabolic phenotypes. METHODS: Data on 345 adults from western Mexico were analyzed. The individuals were classified into NW and EW groups according to body mass index, and were categorized as MH or metabolically unhealthy (MUH), considering homeostatic model assessment insulin resistance (HOMA-IR) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) cut-off points for glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure. Subjects with ≤1 altered parameter were classified as MH. The single nucleotide polymorphisms (SNPs) -11377C>G, -11391G>A, +45T>G, and +276G>T for ADIPOQ and Pro12Ala for PPARG were analyzed by allelic discrimination. High-molecular-weight adiponectin isoform levels were measured by ELISA. RESULTS: Lower serum adiponectin levels were associated with the MUH phenotype in EW subjects. NW subjects with the GG or TG genotype for the +45T>G SNP had reduced odds of the MUH phenotype. Individuals who carried two copies of the GG haplotype at the -11391G>A and -11377C>G SNPs for ADIPOQ had lower serum adiponectin levels than those with zero copies. CONCLUSION: In this population, lower serum adiponectin levels were found in the EW-MUH phenotype, and no differences were observed between the NW-MH and the EW-MH phenotype. In addition, the +45T>G SNP was associated with reduced odds of the MUH phenotype.
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Torres‐Castillo et al. (2020) conducted a cross-sectional in Metabolically unhealthy phenotype (n=345). ADIPOQ and PPARG genetic variants vs. Reference genotypes was evaluated on Metabolically unhealthy phenotype and serum adiponectin levels. The +45T>G SNP in ADIPOQ was associated with reduced odds of the metabolically unhealthy phenotype in normal-weight subjects, and the GG haplotype was linked to lower serum adiponectin levels.
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