What question did this study set out to answer?

To review metabolite modulation across the placenta and quantify the transfer rates of D-glucose, L-alanine, and glycerol under normal and altered maternal metabolic states.

September 24, 2009Biology of the NeonateOpen Access

Maternal Factors Modulating Nutrient Transfer to Fetus

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Authors

MLMiguel A. LasunciónInstituto Cajal JLJosé Ramón Fernández LorenzoUniversity of Miami MPManuel Palacı́nInstituto de Salud Carlos III

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Implication

Experimental study reveals maternal metabolite levels and uterine blood flow dictate placental nutrient transfer in pregnant rats, highlighting maternal metabolic control of fetal growth.

Key Points

To review metabolite modulation across the placenta and quantify the transfer rates of D-glucose, L-alanine, and glycerol under normal and altered maternal metabolic states.
Infused 14C-labelled D-glucose, L-alanine, or glycerol into the left uterine artery of 21-day pregnant rats.
Calculated placental transfer by adjusting fetal radioactivity for maternal arterial tracer dilution and uterine blood flow across control, 48-hour starved, and streptozotocin-induced diabetic groups.
Placental transfer rates in late pregnancy reached 127 mumol X kg-1 fetal b.w. X min-1 for D-glucose, 23 for L-alanine, and 1 for glycerol.
Placental metabolite transfer varied in parallel with maternal arterial concentrations, showing reduced glucose transfer during fasting hypoglycemia and major increases during diabetes.
Both 48-hour starvation and streptozotocin-induced diabetes markedly reduced placental blood flow and diminished the transport of L-alanine to the fetus.

Cite This Study

Lasunción et al. (2009) studied this question.

synapsesocial.com/papers/6a845edd3dbf2f1b7f68c2bc https://doi.org/10.1159/000242637

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Implication

Experimental study reveals maternal metabolite levels and uterine blood flow dictate placental nutrient transfer in pregnant rats, highlighting maternal metabolic control of fetal growth.

Maternal Factors Modulating Nutrient Transfer to Fetus

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal Factors Modulating Nutrient Transfer to Fetus

Discussion

Member takes

Implication

Key Points

Cite This Study

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