Key result
The AA genotype of the AT2R -1332 G:A polymorphism was significantly more frequent in female T2DM patients with diabetic nephropathy compared to those without (50% vs 13.3%).
Why the study?
Does the AT2R -1332 G:A polymorphism associate with the risk of diabetic nephropathy and coronary artery disease in patients with type 2 diabetes mellitus?
Case-Control (n=182)
No
Does the AT2R -1332 G:A polymorphism associate with the risk of diabetic nephropathy and coronary artery disease in patients with type 2 diabetes mellitus?
Absolute Event Rate: 50% vs 13.3%
p-value: p=0.015
The AT2R -1332 G:A polymorphism is associated with an increased risk of diabetic nephropathy in females and an increased risk of coronary artery disease in diabetic patients without nephropathy.
AA genotype may raise nephropathy risk in female T2DM patients; hypothesis-generating for CAD and needs validation before any clinical use.
No takes yet. Share an insight, caveat, or question.
Rahimi et al. (2013) conducted a case-control in Type 2 diabetes mellitus and diabetic nephropathy (n=182). AT2R -1332 G:A polymorphism (AA genotype / A allele) vs. G allele / GG+GA genotypes / healthy controls was evaluated on Diabetic nephropathy in female T2DM patients (AA genotype frequency) (p=0.015). The AA genotype of the AT2R -1332 G:A polymorphism was significantly more frequent in female T2DM patients with diabetic nephropathy compared to those without (50% vs 13.3%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: