February 1, 1998Journal of Internal Medicine

The activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure

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Structured PICO

Population

53 patients with congestive heart failure (28 NYHA class I-II, 25 NYHA class III-IV), mean age 46 ± 16 years, 50 male and 3 female.

Outcome

Relationship between plasma renin activity, angiotensin II, serum levels of angiotensin-converting enzyme, aldosterone and markers of immune activation (neopterin, soluble TNF receptors, IL-2 receptors)surrogate

Demonstrates a weak but significant correlation between RAAS activation and immune system markers in patients with congestive heart failure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not yet change HF management; leaves open whether immune-RAAS links warrant prospective study.

Cite This Study

Lopatin et al. (1998) studied this question.

synapsesocial.com/papers/6a8466f0309bd08d91731abe https://doi.org/10.1046/j.1365-2796.1998.00240.x

Topics

Heart failure HFrEF treatment

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The activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

The activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider