Key result
Fetal epicardial fat thickness measured at 18-22 weeks of gestation was significantly higher in women with gestational diabetes mellitus compared to healthy controls (1.05 mm vs 0.8 mm, p<0.01), with a cutoff >0.95 mm predicting GDM with an odds ratio of 13.
Why the study?
To evaluate whether fetal epicardial fat thickness changes before 24 weeks of gestation can predict gestational diabetes mellitus and correlate with maternal HbA1C values.
Does fetal epicardial fat thickness (fEFT) measured at 18-22 weeks of gestation predict gestational diabetes mellitus (GDM) diagnosis?
Case-Control (n=120)
Does fetal epicardial fat thickness (fEFT) measured at 18-22 weeks of gestation predict gestational diabetes mellitus (GDM) diagnosis?
Absolute Event Rate: 1.05% vs 0.8%
p-value: p=<0.01
Fetal epicardial fat thickness measured at 18-22 weeks of gestation is significantly increased in GDM and can serve as an early sonographic predictor for the condition.
BACKGROUND: Gestational diabetes mellitus (GDM) is defined as the new onset of impairment in carbohydrate tolerance during pregnancy. The aim of the current study was to define fetal epicardial fat thickness (fEFT) changes that developed before 24 weeks of gestation, to evaluate the diagnostic effectiveness of fEFT in predicting GDM diagnosis, and to correlate fEFT values with hemoglobin A1C (HbA1C) values. METHODS: The study included a total of 60 GDM patients and 60 control subjects. A record consisted of fEFT measurements, maternal body mass index, maternal subcutaneous fat thickness, and fetal subcutaneous fat thickness during sonographic screening performed at 18-22 gestational weeks. Fetal abdominal circumference (AC) values, estimated fetal weight (EFW), and fetal gender were also recorded. RESULTS: < 0.01). According to the receiver operating characteristic analysis results, a fEFT value of > 0.95 can predict GDM diagnosis with sensitivity of 65% and specificity of 88% (odds ratio = 13). CONCLUSION: fEFT values are increased in GDM cases, and the increase can be detected earlier than 24 weeks of gestation. fEFT values are positively correlated with HbA1C values and can serve as an early predictor for GDM diagnosis.
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Aydın et al. (2020) conducted a case-control in Gestational diabetes mellitus (n=120). Fetal epicardial fat thickness (fEFT) vs. Healthy pregnant controls was evaluated on Median fetal epicardial fat thickness (fEFT) in mm (p=<0.01). Fetal epicardial fat thickness measured at 18-22 weeks of gestation was significantly higher in women with gestational diabetes mellitus compared to healthy controls (1.05 mm vs 0.8 mm, p<0.01), with a cutoff >0.95 mm predicting GDM with an odds ratio of 13.
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