Key result
Epicardial adipose tissue thickness ≥ 7 mm was independently associated with impaired aortic elastic properties, including lower aortic strain and higher aortic stiffness index.
Why the study?
Is increased epicardial adipose tissue thickness associated with increased aortic stiffness in patients with newly diagnosed primary hypertension?
Cross-Sectional (n=144)
Is increased epicardial adipose tissue thickness associated with increased aortic stiffness in patients with newly diagnosed primary hypertension?
Increased epicardial adipose tissue thickness is independently associated with impaired aortic elastic properties in patients with newly diagnosed, untreated primary hypertension.
Supports hypothesis of epicardial fat contributing to aortic stiffness in new hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.
AIMS: In patients with hypertension (HT), increased aortic stiffness is related to higher cardiovascular morbidity and mortality. Recent investigations have shown that epicardial adipose tissue (EAT) is a new potential cardiometabolic risk factor. The aim of our study was to examine the relation between echocardiographically measured EAT thickness and aortic stiffness in patients with primary HT. METHODS: The study included 144 newly diagnosed and untreated essential hypertensive outpatients. Transthoracic echocardiographic EAT thickness and aortic stiffness measurements were performed for all study participants. Afterwards patients were divided in two groups according to their median EAT thickness values. The patients with EAT thickness of < 7 mm were included in group 1 and patients with EAT thickness of ≥ 7 mm were included in group 2. RESULTS: Aortic strain and distensibility parameters of group 2 were lower than in group 1. The aortic stiffness index of group 2 was found to be higher than group 1. Multivariate regression analysis revealed that EAT thickness was the only independent variable for all three parameters of aortic stiffness index, aortic strain and aortic distensibility. CONCLUSION: In patients with newly diagnosed primary HT, increased EAT thickness was significantly linked to impaired aortic elastic properties independently of other conventional adiposity measurements.
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Doğan et al. (2013) conducted a cross-sectional in Primary hypertension (n=144). Epicardial adipose tissue (EAT) thickness ≥ 7 mm vs. EAT thickness < 7 mm was evaluated on Aortic stiffness index, aortic strain, and aortic distensibility. Epicardial adipose tissue thickness ≥ 7 mm was independently associated with impaired aortic elastic properties, including lower aortic strain and higher aortic stiffness index.
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