Key result
Echocardiographically measured epicardial adipose tissue thickness was significantly increased in patients with prehypertension (5.4 mm) and hypertension (6.6 mm) compared to normotensive subjects (4.1 mm).
Cross-Sectional (n=150)
No
Absolute Event Rate: 5.4% vs 4.1%
p-value: p=<0.001
Epicardial adipose tissue thickness is significantly increased in prehypertensive patients and correlates positively with blood pressure levels, suggesting a potential role of visceral adiposity in early hypertension development.
May signal early hypertension risk; hypothesis-generating for epicardial fat's role, needs longitudinal confirmation before clinical use.
OBJECTIVES: Increased epicardial adipose tissue (EAT) thickness is a risk factor for cardiovascular diseases. Previous studies have demonstrated that EAT thickness is increased in patients with hypertension compared with normotensive individuals. In the current study, we aimed to evaluate whether echocardiographically measured EAT thickness differs among patients with normotension, prehypertension, hypertension, and the relation between EAT thickness and blood pressure levels in prehypertensives. STUDY DESIGN: Patients with prehypertension (n=50) and hypertension (n=50) and normotensive healthy subjects (n=50) according to the American Hypertension Guidelines (Joint National Committee 7) were enrolled in the study. All participants underwent transthoracic echocardiographic examination. EAT thickness was measured from the parasternal long-axis view at end-systole. RESULTS: Compared with normotensives, EAT thickness was significantly increased in subjects with prehypertension and hypertension (4.1±1.1 mm, 5.4±1.3 mm and 6.6±1.5 mm, respectively, p<0.001). After adjustment for confounding factors like age, gender, high-density lipoprotein, waist circumference, and body mass index, EAT thickness in the normotensive, prehypertensive and hypertensive groups was measured as 4.3±1.2 mm, 5.3±1.2 mm and 6.4±1.4 mm, respectively (p=0.001). In the prehypertensive group, multivariable linear regression analysis showed that EAT thickness was positively correlated with both systolic (r=0.305, p=0.001) and diastolic (r=0.297, p=0.001) blood pressures, independent of other risk factors. CONCLUSION: In addition to hypertensive subjects, echocardiographically measured EAT thickness is increased in prehypertensive patients when compared with normotensive subjects, independent of other factors. Additionally, increased EAT thickness is significantly correlated with systolic and diastolic blood pressure levels in patients with prehypertension.
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Osman Turak (2014) conducted a cross-sectional in Prehypertension and Hypertension (n=150). Prehypertension and hypertension vs. Normotension was evaluated on Epicardial adipose tissue (EAT) thickness (p=<0.001). Echocardiographically measured epicardial adipose tissue thickness was significantly increased in patients with prehypertension (5.4 mm) and hypertension (6.6 mm) compared to normotensive subjects (4.1 mm).
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