Key result
Nephrotic syndrome in children was associated with significantly higher epicardial adipose tissue and increased atrial depolarization and ventricular repolarization parameters compared to controls.
Why the study?
Patients with nephrotic syndrome are at high risk of cardiovascular disease, obesity, and dyslipidemia, prompting evaluation of epicardial adipose tissue formation and electrocardiographic parameters.
Do pediatric patients with nephrotic syndrome have increased epicardial adipose tissue and altered ECG parameters compared to controls?
Case-Control (n=47)
Do pediatric patients with nephrotic syndrome have increased epicardial adipose tissue and altered ECG parameters compared to controls?
Pediatric patients with nephrotic syndrome exhibit increased epicardial adipose tissue and altered ECG parameters, suggesting these may serve as early noninvasive markers of cardiovascular risk.
May support early CV risk monitoring in pediatric nephrotic syndrome; hypothesis-generating, needs prospective validation before practice change.
BACKGROUND: Patients with nephrotic syndrome (NS) are at a high risk of cardiovascular disease, obesity, and dyslipidemia. The aim of this study was to evaluate the formation of epicardial adipose tissue (EAT) and investigate electrocardiographic (ECG) parameters in patients. METHODS: Thirty-two patients aged 0-18 years and 15 control patients were compared. In the patient group, physical examination and laboratory parameters were recorded. Atrial depolarization and ventricular repolarization parameters in ECG were compared between the groups. EAT was evaluated with M-mode measurements on echocardiography. RESULTS: There was no difference between the groups in terms of sex, age, body mass index, systolic and diastolic BP. EAT was found to be significantly higher in the patient group. In ECG evaluations it was determined that atrial depolarization and ventricular repolarization parameters increased in the patient group. CONCLUSIONS: Cardiovascular morbidity and mortality are high in kidney diseases. Measurement and follow-up of EAT and ECG findings as a noninvasive parameter can provide information in NS.
No takes yet. Share an insight, caveat, or question.
Şimşek et al. (2022) conducted a case-control in Nephrotic syndrome (n=47). Nephrotic syndrome vs. Control patients was evaluated on Epicardial adipose tissue (EAT) and electrocardiographic (ECG) parameters. Nephrotic syndrome in children was associated with significantly higher epicardial adipose tissue and increased atrial depolarization and ventricular repolarization parameters compared to controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: