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September 30, 2021Pakistan Heart JournalOpen Access

The Relationship Between Epicardial Fat Tissue Thickness and Risk of Frequent Premature Ventricular Contractions

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Key result

Higher epicardial fat tissue thickness was not significantly associated with an increased risk of frequent premature ventricular contractions in patients without structural heart disease (OR 1.14, p=0.669).

Why the study?

The study was conducted to evaluate the relationship between epicardial fat tissue thickness and frequent premature ventricular contractions.

Does epicardial fat tissue thickness correlate with frequent premature ventricular contractions in patients without structural heart disease?

Population

50 patients with no structural heart diseases diagnosed with PVCs on 24-hour Holter monitoring

Comparison

Frequent PVCs (>10 per hour) vs non-frequent PVCs

Design

Cross-sectional study

Authors

SMSeyedeh Fatemeh MirrazeghiGuilan University of Medical SciencesSSShadi ShabahangAVAzin VakilpourCross-Cutting Cardiology

Discussion

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Implication

EFT thickness should not inform PVC risk assessment without structural heart disease; leaves open its links with age and IVSD for prospective study.

Study Design

Type

Cross-Sectional (n=50)

Multicenter

No

Structured PICO

Does epicardial fat tissue thickness correlate with frequent premature ventricular contractions in patients without structural heart disease?

P
Population
50 adult patients without structural heart disease who experienced premature ventricular contractions on 24-hour Holter monitoring were evaluated in a cross-sectional study.
E
Exposure
Epicardial fat tissue (EFT) thickness measurement by 2-dimensional transthoracic echocardiography
C
Comparator
Patients with PVC < 10 per hour vs PVC > 10 per hour
O
Outcome
Association between EFT thickness and frequent PVCs (>10 per hour)surrogate

Main Result

Odds Ratio: 1.14 (95% CI 0.62–2.07)

p-value: p=0.669

In patients without structural heart disease, frequent PVCs are associated with higher left ventricular end-diastolic and left atrial diameters, but not significantly with epicardial fat tissue thickness.

Limitations

  • Small sample size
  • Cross-sectional design limits causal relationships between EFT, PVCs and related factors
  • EFT was assessed only by 2D transthoracic echocardiography, without computed tomography or magnetic resonance imaging
  • Cross-sectional design limits causal relationships
  • EFT assessed only by 2D transthoracic echocardiography (no computed tomography or magnetic resonance imaging)

Cite This Study

Mirrazeghi et al. (2021) conducted a cross-sectional in Premature ventricular contractions (n=50). Epicardial fat tissue (EFT) thickness vs. Lower EFT thickness was evaluated on Frequent premature ventricular contractions (>10 per hour) (OR 1.14, 95% CI 0.62-2.07, p=0.669). Higher epicardial fat tissue thickness was not significantly associated with an increased risk of frequent premature ventricular contractions in patients without structural heart disease (OR 1.14, p=0.669).

synapsesocial.com/papers/6a846a0ec7e37ebe3168dc3ahttps://doi.org/10.47144/phj.v54i3.2112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial adipose tissue and its association with cardiovascular risk factors and mitral annular calcium deposits2019 · 16 citations
  2. 2Is epicardial fat depot associated with atrial fibrillation? A systematic review and meta-analysis2017 · 119 citations
  3. 3A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome2019 · 6 citations
  4. 4Are premature ventricular contractions always harmless?2013 · 14 citations
  5. 5Electrocardiographic (ECG) clues to differentiate idiopathic right ventricular outflow tract tachycardia (RVOTT) from arrhythmogenic right ventricular cardiomyopathy (ARVC)2014 · 9 citations