Key result
A single bout of mild-to-moderate dynamic exercise significantly attenuated the pressor response to graded colon distension in T5 spinal rats.
Why the study?
Does acute mild-to-moderate dynamic exercise reduce the pressor response to colon distension in T5 spinal rats?
Does acute mild-to-moderate dynamic exercise reduce the pressor response to colon distension in T5 spinal rats?
Acute mild-to-moderate dynamic exercise significantly attenuates the pressor response to colon distension in a rat model of spinal cord injury, suggesting a potential therapeutic approach for autonomic dysreflexia.
Answers are grounded in this paper and cite their sources.
May inform exercise for autonomic dysreflexia; leaves open translation beyond this animal model.
Individuals with spinal cord injuries above thoracic level 6 (T(6)) experience life-threatening bouts of hypertension, termed autonomic dysreflexia (AD). AD is mediated by peripheral alpha-adrenergic receptor supersensitivity as well as a reorganization of spinal pathways controlling sympathetic preganglionic neurons. A single bout of dynamic exercise may be a safe therapeutic approach to reduce the severity of AD because mild-to-moderate dynamic exercise reduces postexercise alpha-adrenergic receptor responsiveness, lowers postexercise sympathetic nerve activity, and reduces the postexercise response to stress. Therefore, this study was designed to test the hypothesis that mild-to-moderate dynamic exercise attenuates the postexercise response to colon distension (mechanism to elicit AD). To test this hypothesis, six male Wistar rats (406 +/- 23 g), 5 wk post-T(5) spinal cord transection, were instrumented with an arterial catheter. After recovery, the response to graded colon distension (10, 30, 50, and 80 mmHg, in random order) was determined before and after a single bout of mild-to-moderate dynamic exercise (9-12 m/min, 0% grade for 40 min). After exercise, the pressor response to graded colon distension was significantly attenuated (preexercise change: 2 +/- 1, 9 +/- 1, 14 +/- 1, and 24 +/- 2 vs. postexercise change: 2 +/- 1, 2 +/- 1, 9 +/- 1, and 12 +/- 3 mmHg). Thus acute exercise is a safe, therapeutic approach to reduce the severity of AD in paraplegic subjects.
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Collins et al. (2002) studied Autonomic dysreflexia (n=6). Mild-to-moderate dynamic exercise vs. Pre-exercise baseline was evaluated on Pressor response to graded colon distension. A single bout of mild-to-moderate dynamic exercise significantly attenuated the pressor response to graded colon distension in T5 spinal rats.
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