December 1, 1999Journal of General Virology

Comparative analysis of virus–host cell interactions of haemagglutinating and non-haemagglutinating strains of coxsackievirus B3

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Population

HeLa cells infected with two strains of coxsackievirus B3

Design

Preclinical

Authors

APAndreas PaschJohannes Kepler University of Linz JKJan‐Heiner KüpperBrandenburg University of Technology Cottbus-Senftenberg AWAntje WoldeUniversitätsklinikum Tübingen

Discussion

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Implication

Co-targeting DAF and CAR merits exploration as CVB3 therapy; leaves open clinical translation from animal data.

Structured PICO

Population

HeLa cells infected with two strains of coxsackievirus B3 (non-haemagglutinating CBV3 and haemagglutinating CBV3-HA)

Intervention

Anti-DAF and anti-CAR antibodies (alone or in combination)

Outcome

Virus binding and productive infectionsurrogate

Both haemagglutinating and non-haemagglutinating strains of coxsackievirus B3 preferentially interact with closely associated DAF and CAR proteins on host cells.

Cite This Study

Pasch et al. (1999) studied this question.

synapsesocial.com/papers/6a846b24c7e37ebe3168dc95 https://doi.org/10.1099/0022-1317-80-12-3153

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Comparative analysis of virus–host cell interactions of haemagglutinating and non-haemagglutinating strains of coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparative analysis of virus–host cell interactions of haemagglutinating and non-haemagglutinating strains of coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider