Why the study?
Does interaction with decay-accelerating factor (DAF) facilitate coxsackievirus B infection of polarized epithelial cells?
Population
Polarized epithelial cells and coxsackievirus B (CB3 and CB5) isolates
Comparison
DAF-binding isolates of CB3 and CB5 / anti-DAF… vs Isolates incapable of attaching to DAF / absence…
Design
Preclinical
Authors
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DAF may facilitate coxsackie B epithelial entry; leaves open relevance to human disease and therapeutic targeting.
Does interaction with decay-accelerating factor (DAF) facilitate coxsackievirus B infection of polarized epithelial cells?
Interaction with decay-accelerating factor (DAF) on the apical surface of polarized epithelial cells facilitates infection by a subset of coxsackievirus B isolates.
Shieh et al. (2002) studied this question.
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