Key result
Etomidate (0.3mg/kg) and propofol (2mg/kg) showed no significant difference in post-operative Ramsey sedation scale scores (2.1 vs 2.18, p=0.637) during induction of anaesthesia.
Why the study?
Does intravenous etomidate compared to propofol reduce side effects or improve safety during induction of anaesthesia and endotracheal intubation?
Does intravenous etomidate compared to propofol reduce side effects or improve safety during induction of anaesthesia and endotracheal intubation?
Absolute Event Rate: 2.1% vs 2.18%
p-value: p=0.637
Etomidate and propofol demonstrate similar rates of post-operative nausea, vomiting, and sedation, but etomidate is associated with a significantly higher incidence of myoclonus during anesthesia induction.
Etomidate was associated with higher myoclonus without sedation or PONV benefit; observational data leaves open any safety advantage during induction.
Patients given propofol should be constantly monitored and facilities for maintenance of a patient airway, artificial ventilation, oxygen enrichment and other resuscitative facilities should be readily available at all times. Apnoea often occurs during induction and may persist for more than 60 seconds. Group 1 patient following premedication receives injection Propofol 2mg/kg i.v. and group 2 patient following premedication receives inj. Etomidate 0.3mg/kg i.v. for induction of anaesthesia. Required parameters in haemodynamics and side effects were compared with the help of proforma data analysis. the mean value of Ramsey sedation scale for etomidate group was 2.1 ± 0.58 whereas it was 2.18 ± 0.75 for propofol group. There was no statistical significance between both groups on inter-group analysis.
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Koshy et al. (2021) studied Induction of anaesthesia (n=100). Etomidate vs. Propofol 2mg/kg i.v. was evaluated on Ramsey sedation scale score (p=0.637). Etomidate (0.3mg/kg) and propofol (2mg/kg) showed no significant difference in post-operative Ramsey sedation scale scores (2.1 vs 2.18, p=0.637) during induction of anaesthesia.
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