What question did this study set out to answer?

To examine the relationship between platelet aggregation defects and platelet adenine nucleotide levels in patients with myeloproliferative disorders.

January 1, 1979Thrombosis and Haemostasis

Abnormalities of Platelet Adenine Nucleotides in Patients with Myeloproliferative Disorders

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Authors

JNJunji NishimuraFukuoka Institute of Technology SOS OkamotoKyushu University HIHiroshi IbayashiThe University of Tokyo

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Implication

Observational study reveals defective platelet aggregation linked to reduced releasable ADP in myeloproliferative disorders, indicating storage pool deficiency.

Key Points

To examine the relationship between platelet aggregation defects and platelet adenine nucleotide levels in patients with myeloproliferative disorders.
Assessed platelet aggregation induced by ADP and collagen in 13 patients with myeloproliferative disorders compared with normal subjects.
Measured resting concentrations and post-collagen stimulation release of ATP and ADP in platelets.
Collagen-induced platelet aggregation was impaired in 11 of 13 patients, while ADP-induced aggregation was abnormal in 2 patients.
Patients with impaired aggregation exhibited significantly reduced resting concentrations of ATP and ADP and marked reduction in nucleotide release after collagen stimulation compared to normal subjects.
Platelet dysfunction in myeloproliferative disorders was predominantly attributable to a reduction in releasable ADP.

Cite This Study

Nishimura et al. (1979) studied this question.

synapsesocial.com/papers/6a84787225efb1e71e83fcb2 https://doi.org/10.1055/s-0038-1646838

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Implication

Observational study reveals defective platelet aggregation linked to reduced releasable ADP in myeloproliferative disorders, indicating storage pool deficiency.

Abnormalities of Platelet Adenine Nucleotides in Patients with Myeloproliferative Disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

Abnormalities of Platelet Adenine Nucleotides in Patients with Myeloproliferative Disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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