What question did this study set out to answer?

To identify age-related differences in primary hemostasis and assess whether whole-blood platelet aggregation predicts in vitro and in vivo hemostatic function.

June 1, 1995Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Whole-Blood Platelet Aggregation Predicts In Vitro and In Vivo Primary Hemostatic Function in the Elderly

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Why the study?

Does whole-blood platelet aggregation predict primary hemostatic function differently in elderly versus young blood donors?

Key Points

To identify age-related differences in primary hemostasis and assess whether whole-blood platelet aggregation predicts in vitro and in vivo hemostatic function.
Evaluated 37 elderly and 31 young blood donors.
Measured whole-blood platelet aggregation stimulated by collagen, arachidonic acid, and ADP, alongside bleeding time and plasma levels of fibrinogen and activated factor VII.
Assessed platelet adherence and thrombus formation on human umbilical artery segments in vitro.
Collagen-induced platelet aggregation was significantly correlated with platelet adherence to the subendothelium (r = .488, P = .002) and inversely correlated with bleeding time (r = -.401, P = .014) only in elderly donors.
In elderly men, arachidonic acid-induced aggregation significantly correlated with subendothelial adherence (r = .658, P = .003) and bleeding time (r = -.540, P = .021).
Baseline whole-blood platelet aggregation, thrombus formation, and bleeding times showed no significant age-related differences, though plasma fibrinogen was elevated in elderly donors and activated factor VII was higher exclusively in elderly women.

Structured PICO

Does whole-blood platelet aggregation predict primary hemostatic function differently in elderly versus young blood donors?

Population

68 blood donors (37 elderly and 31 young)

Intervention

Whole-blood platelet aggregation testing (collagen, arachidonic acid, and ADP-induced)

Comparator

Young blood donors

Outcome

Primary hemostatic function (platelet adherence, thrombus formation on human umbilical artery segments, and bleeding time)surrogate

Whole-blood platelet aggregation in response to collagen and arachidonic acid may be more useful in predicting primary hemostatic function and coronary risk in the elderly than in the young.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May suggest greater utility of aggregation testing for hemostatic function in the elderly; leaves open its role in coronary risk assessment.

Cite This Study

Emery et al. (1995) studied this question.

synapsesocial.com/papers/6a8478b0d87e21f83cb2a041 https://doi.org/10.1161/01.atv.15.6.748

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Implication

May suggest greater utility of aggregation testing for hemostatic function in the elderly; leaves open its role in coronary risk assessment.

Whole-Blood Platelet Aggregation Predicts In Vitro and In Vivo Primary Hemostatic Function in the Elderly

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Whole-Blood Platelet Aggregation Predicts In Vitro and In Vivo Primary Hemostatic Function in the Elderly

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider