August 1, 1995Angiology

The Effect of Ageing on Platelet Function and Fibrinolytic Activity

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Why the study?

Does ageing and vigorous cycling exercise affect platelet aggregation and fibrinolytic activity in healthy male volunteers?

Population

24 healthy male volunteers, comprising 12 young and 12 middle-aged.

Comparison

Vigorous cycling exercise vs Resting state; and comparison between young and…

Design

Cross-sectional

Authors

GGG. GleerupUniversity of Copenhagen KWK. WintherUniversity of Copenhagen

Discussion

Member takes

Overview

May signal heightened thrombotic risk with middle age; hypothesis-generating for age-specific exercise effects on hemostasis.

Structured PICO

Does ageing and vigorous cycling exercise affect platelet aggregation and fibrinolytic activity in healthy male volunteers?

Population

24 healthy male volunteers, comprising 12 young (mean age 25, range 21-30 years) and 12 middle-aged (mean age 58, range 44-72 years).

Intervention

Vigorous cycling exercise

Comparator

Resting state; and comparison between young and middle-aged groups

Outcome

Platelet aggregation induced by adenosine diphosphate and fibrinolytic activity (estimated as euglobulin clot lysis time [ECLT], tissue plasminogen activator [t-PA], and PAI-1)surrogate

Increasing age is associated with increased platelet aggregability and decreased fibrinolytic activity, while vigorous exercise decreases platelet aggregability only in young individuals.

Cite This Study

Gleerup et al. (1995) studied this question.

synapsesocial.com/papers/6a8478b0d87e21f83cb2a040 https://doi.org/10.1177/000331979504600810

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August 1, 1995Angiology

The Effect of Ageing on Platelet Function and Fibrinolytic Activity

View Full Paper

Ask AI

Bookmark

Why the study?

Does ageing and vigorous cycling exercise affect platelet aggregation and fibrinolytic activity in healthy male volunteers?

Population

24 healthy male volunteers, comprising 12 young and 12 middle-aged.

Comparison

Vigorous cycling exercise vs Resting state; and comparison between young and…

Design

Cross-sectional

Authors

GGG. GleerupUniversity of Copenhagen KWK. WintherUniversity of Copenhagen

Discussion

Member takes

Overview

May signal heightened thrombotic risk with middle age; hypothesis-generating for age-specific exercise effects on hemostasis.

Structured PICO

Does ageing and vigorous cycling exercise affect platelet aggregation and fibrinolytic activity in healthy male volunteers?

Population

24 healthy male volunteers, comprising 12 young (mean age 25, range 21-30 years) and 12 middle-aged (mean age 58, range 44-72 years).

Intervention

Vigorous cycling exercise

Comparator

Resting state; and comparison between young and middle-aged groups

Outcome

Platelet aggregation induced by adenosine diphosphate and fibrinolytic activity (estimated as euglobulin clot lysis time [ECLT], tissue plasminogen activator [t-PA], and PAI-1)surrogate

Increasing age is associated with increased platelet aggregability and decreased fibrinolytic activity, while vigorous exercise decreases platelet aggregability only in young individuals.

Cite This Study

Gleerup et al. (1995) studied this question.

synapsesocial.com/papers/6a8478b0d87e21f83cb2a040 https://doi.org/10.1177/000331979504600810

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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