Population
Porcine model of normal and briefly ischaemic and reperfused myocardium
Comparison
Left anterior descending coronary artery… vs Sham operated and non-ischaemic myocardial tissues
Design
Preclinical
Follow-up
Up to 210 minutes of reperfusion
Authors
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Highlights molecular stress responses in porcine stunned myocardium; leaves open human relevance and therapeutic targeting.
Brief ischemia and reperfusion in a porcine model induces transient increases in ubiquitin and hsp27 mRNA expression, indicating molecular damage in stunned myocardium.
Andres et al. (1993) studied this question.
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