November 1, 1984AJP Renal Physiology

Angiotensin II in adrenergic-induced alterations in glomerular hemodynamics

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Why the study?

Does Angiotensin II inhibition modulate the effects of renal nerve stimulation on glomerular hemodynamics in Munich-Wistar rats?

Population

Munich-Wistar rats

Comparison

Angiotensin II inhibition via intravenous… vs Renal nerve stimulation alone

Design

Preclinical

Authors

JPJ. C. PelayoChildren's Hospital of Los Angeles MZM. G. ZieglerUniversity of California, San Diego RBRoland C. BlantzUniversity of California, San Diego

Discussion

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Implication

Ang II mediates renal nerve effects on rat SNGFR; hypothesis-generating for human neurohormonal glomerular control.

Structured PICO

Does Angiotensin II inhibition modulate the effects of renal nerve stimulation on glomerular hemodynamics in Munich-Wistar rats?

Population

Munich-Wistar rats

Intervention

Angiotensin II inhibition via intravenous administration of [Sar1, Ala8] angiotensin II or MK 421 during moderate-frequency (3-Hz) renal nerve stimulation

Comparator

Renal nerve stimulation alone (measurements obtained before ANG II-inhibition)

Outcome

Glomerular ultrafiltration (SNGFR) and vascular resistancessurrogate

Angiotensin II is a critical factor for the full functional expression of renal nerve stimulation on glomerular hemodynamics.

Cite This Study

Pelayo et al. (1984) studied this question.

synapsesocial.com/papers/6a848877c2c8a33f31f7b623 https://doi.org/10.1152/ajprenal.1984.247.5.f799

View Full Paper

Ask AI

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Angiotensin II in adrenergic-induced alterations in glomerular hemodynamics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II in adrenergic-induced alterations in glomerular hemodynamics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider