Key result
One-kidney, one-clip hypertension in mice induced tachycardia, elevated sympathetic tone, reduced vagal tone, and concentric cardiac hypertrophy at 1 and 4 weeks, with fibrosis appearing at 4 weeks.
Why the study?
Does the one-kidney, one-clip (1K1C) hypertension model induce hemodynamic, neurohumoral, and structural cardiac changes in mice?
Population
Conscious mice
Design
Preclinical
Follow-up
1 and 4 weeks
Authors
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Supports 1K1C mouse model for hypertension research; leaves open translation to human disease.
Does the one-kidney, one-clip (1K1C) hypertension model induce hemodynamic, neurohumoral, and structural cardiac changes in mice?
The 1K1C hypertensive mouse model exhibits early neurohumoral changes and progressive cardiac hypertrophy and fibrosis, making it a useful tool for studying ANG II-dependent and independent hypertension.
Borges et al. (2008) studied one-kidney, one-clip (1K1C) hypertension. One-kidney, one-clip (1K1C) surgery was evaluated on Sympathovagal balance and baroreflex control of heart rate. One-kidney, one-clip hypertension in mice induced tachycardia, elevated sympathetic tone, reduced vagal tone, and concentric cardiac hypertrophy at 1 and 4 weeks, with fibrosis appearing at 4 weeks.
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