Key result
Prehospital aspirin administration was associated with lower 30-day mortality compared with administration after hospital arrival in patients with suspected acute coronary syndrome.
Why the study?
Does prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals reduce mortality in adult patients with suspected ACS?
Systematic Review (n=4,350)
Does prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals reduce mortality in adult patients with suspected ACS?
Prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals may reduce 30-day and 1-year mortality in patients with suspected ACS, though the certainty of evidence is very low.
Answers are grounded in this paper and cite their sources.
May support prehospital aspirin and nitroglycerin in suspected ACS; leaves open need for RCTs.
Our systematic reviews suggest that prehospital administration of aspirin and nitroglycerin by non-physician healthcare professionals is beneficial for patients with suspected ACS, although the certainty of evidence is very low. Further investigation is needed to determine the benefit of the prehospital administration of these agents.
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Nakayama et al. (2022) conducted a systematic review in Suspected Acute Coronary Syndrome (n=4,350). Prehospital administration of aspirin vs. Aspirin administration after arrival at hospital was evaluated on 30-day mortality (OR 0.59, 95% CI 0.35-0.99, p=<0.01). Prehospital aspirin administration was associated with lower 30-day mortality compared with administration after hospital arrival in patients with suspected acute coronary syndrome.
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