Key result
Aerobic exercise training significantly reduced oxidized HDL from 0.99 to 0.90 (p=0.03) in hypertensive patients, whereas isometric exercise did not.
Why the study?
Exercise training increases HDL cholesterol, but its effect on HDL function is unclear, particularly regarding the impact of different exercise modalities in patients with hypertension.
Does aerobic or isometric exercise improve HDL function in patients with hypertension?
Population
75 hypertensive patients
Comparison
Handgrip isometric training vs placebo-handgrip vs aerobic exercise training
Design
Prospective randomized controlled trial
Follow-up
12 weeks
Authors
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Supports aerobic exercise to enhance HDL antioxidant function in hypertension; extends evidence distinguishing modality-specific effects on lipid oxidation.
RCT (n=75)
Does aerobic or isometric exercise improve HDL function in patients with hypertension?
p-value: p=0.03
Aerobic exercise, but not isometric exercise, improves the antioxidant function of HDL in patients with hypertension, which correlates with blood pressure reduction.
Pagonas et al. (2019) conducted an RCT in Hypertension (n=75). Aerobic exercise training and handgrip isometric training vs. Placebo-handgrip was evaluated on HDL function (Haptoglobin-HDL and oxidized HDL) (p=0.03). Aerobic exercise training significantly reduced oxidized HDL from 0.99 to 0.90 (p=0.03) in hypertensive patients, whereas isometric exercise did not.
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