Key result
Prolonged electrical stimulation of isolated adult cardiac myocytes in microchambers maintained unimpaired excitation-contraction coupling, with constant Ca2+ transient amplitudes for up to 20 min.
This study demonstrates the feasibility of prolonged electrical stimulation and multiplexed optical monitoring of isolated adult cardiac myocytes in microchambers with unimpaired excitation-contraction coupling.
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Enables prolonged in vitro myocyte protocols; leaves open in vivo validation and clinical translation.
Klauke et al. (2005) studied this question. Stimulation by integrated microelectrodes in microfluidic chambers was evaluated on Action potential duration, intracellular Ca2+ and cell shortening. Prolonged electrical stimulation of isolated adult cardiac myocytes in microchambers maintained unimpaired excitation-contraction coupling, with constant Ca2+ transient amplitudes for up to 20 min.
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