February 24, 2005Journal of Applied Physiology

Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes

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Population

Neonatal rat ventricular cells cultured as confluent monolayers

Design

Preclinical

Authors

CKChae-Ryon KongMassachusetts Institute of Technology NBNenad BursacCross-Cutting Cardiology LTLeslie TungElectrophysiology

Discussion

Member takes

Implication

Should not yet change arrhythmia management; leaves open the role of shear stress in human reentry.

Structured PICO

Population

Neonatal rat ventricular cells cultured as confluent monolayers

Intervention

Localized fluid jet pulses (10 ms, velocities 0.3 to 1.8 m/s) resulting in pressure and shear stresses

Outcome

Triggering of excitation, initiation of a propagated wave, and induction of reentry (quantified as average stimulus success rate [ASSR])surrogate

Mechanical forces such as pressure and shear stress, independent of longitudinal stretch, can trigger mechanoelectrical excitation and reentrant arrhythmias in cardiac tissue.

Cite This Study

Kong et al. (2005) studied this question.

synapsesocial.com/papers/6a76a0475cd26a553f061053 https://doi.org/10.1152/japplphysiol.01084.2004

View Full Paper

Ask AI

Bookmark

Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider