What question did this study set out to answer?

To determine the acute and sustained effects of selective aortic and complete sinoaortic baroreceptor deafferentation on arterial pressure and pressure lability in nonhuman primates.

February 1, 1987AJP Regulatory Integrative and Comparative Physiology

Sinoaortic denervation in the nonhuman primate

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Why the study?

Does sinoaortic denervation increase arterial pressure and its lability in nonhuman primates?

Population

Six adult male baboons (Papio anubis) maintained on a tether system

Comparison

Aortic and combined carotid sinus and aortic… vs Baseline (pre-denervation)

Design

Preclinical

Follow-up

4 weeks

Authors

VBV. S. BishopBishop's University RSRobert E. ShadeTexas Biomedical Research Institute JHJoseph R. HaywoodUniversity of Southern California

Discussion

Member takes

Implication

Elevated pressure after sinoaortic denervation in primates supports baroreflex role; extends rodent data but leaves human translation open.

Key Points

To determine the acute and sustained effects of selective aortic and complete sinoaortic baroreceptor deafferentation on arterial pressure and pressure lability in nonhuman primates.
Monitored six adult male baboons (Papio anubis, N=6) maintained on a tether system for continuous physiological measurement.
Assessed 24-hour mean arterial pressure (MAP) and pressure lability across baseline, post-aortic denervation, and 1- and 4-week intervals following complete sinoaortic deafferentation.
24-hour mean arterial pressure rose from 86 ± 4.0 mmHg at baseline to 105 ± 5.5 mmHg after aortic denervation, reached 129 ± 12.9 mmHg at 1 week post-sinoaortic denervation, and declined to 97 ± 4.4 mmHg by week 4.
Arterial pressure lability showed no change after isolated aortic denervation but remained significantly elevated at both 1 and 4 weeks following complete sinoaortic denervation alongside increased heart rate.

Structured PICO

Does sinoaortic denervation increase arterial pressure and its lability in nonhuman primates?

Population

Six adult male baboons (Papio anubis) maintained on a tether system

Intervention

Aortic and combined carotid sinus and aortic baroreceptor deafferentation (sinoaortic denervation)

Comparator

Baseline (pre-denervation)

Outcome

Mean arterial pressure (MAP) averaged over 24 h, lability of arterial pressure, and heart ratesurrogate

Sinoaortic denervation in nonhuman primates causes an acute increase in arterial pressure and lability, which partially recedes but remains significantly elevated at 4 weeks.

Cite This Study

Bishop et al. (1987) studied this question.

synapsesocial.com/papers/6a8490c174ee596ff2c52978 https://doi.org/10.1152/ajpregu.1987.252.2.r294

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Implication

Elevated pressure after sinoaortic denervation in primates supports baroreflex role; extends rodent data but leaves human translation open.

Sinoaortic denervation in the nonhuman primate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Sinoaortic denervation in the nonhuman primate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider