What question did this study set out to answer?

To determine the cardiovascular and hormonal responses to partial carotid sinus denervation and complete sinoaortic denervation in nonhuman primates.

April 1, 1990AJP Regulatory Integrative and Comparative Physiology

Cardiovascular and neuroendocrine responses to baroreceptor denervation in baboons

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Why the study?

Does baroreceptor denervation alter blood pressure and neuroendocrine responses in baboons?

Population

8 adult male baboons maintained on a tether system

Comparison

Bilateral carotid sinus denervation followed by… vs Intact levels (baseline before denervation)

Design

Preclinical

Follow-up

Up to 4 weeks after SAD

Authors

RSRobert E. ShadeTexas Biomedical Research Institute VBV. S. BishopBishop's University JHJoseph R. HaywoodUniversity of Southern California

Discussion

Member takes

Implication

Complete sinoaortic denervation sustains MAP and sympathetic tone in baboons; leaves open translation to human hypertension.

Key Points

To determine the cardiovascular and hormonal responses to partial carotid sinus denervation and complete sinoaortic denervation in nonhuman primates.
Monitored eight adult male baboons (N=8) instrumented on a continuous tether system to measure mean arterial pressure (MAP) and heart rate (HR).
Sequentially performed bilateral carotid sinus denervation (CSD) followed by aortic arch denervation to produce complete sinoaortic denervation (SAD), tracking hemodynamics and neuroendocrine markers for up to 4 weeks.
Bilateral CSD acutely elevated MAP from 83 ± 2.2 to 124 ± 7.3 mmHg, but MAP gradually returned to intact baseline levels over 14 days alongside transient norepinephrine increases.
SAD produced an immediate pressure surge followed by a sustained MAP increase of 11 mmHg maintained for up to 4 weeks, accompanied by chronically increased blood pressure variability, decreased HR variability, and a 72% elevation in plasma norepinephrine.
Plasma renin activity, vasopressin, and epinephrine levels did not change significantly from intact baseline values after either CSD or SAD.

Structured PICO

Does baroreceptor denervation alter blood pressure and neuroendocrine responses in baboons?

Population

8 adult male baboons maintained on a tether system

Intervention

Bilateral carotid sinus denervation (CSD) followed by denervation of the aortic arch to produce sinoaortic denervation (SAD)

Comparator

Intact levels (baseline before denervation)

Outcome

Mean arterial blood pressure (MAP) and heart rate (HR)surrogate

Complete sinoaortic denervation, but not carotid sinus denervation alone, produces a sustained increase in mean arterial pressure and sympathetic tone in baboons.

Cite This Study

Shade et al. (1990) studied this question.

synapsesocial.com/papers/6a7cc379e98c86b2617cd4be https://doi.org/10.1152/ajpregu.1990.258.4.r930

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Cardiovascular and neuroendocrine responses to baroreceptor denervation in baboons

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular and neuroendocrine responses to baroreceptor denervation in baboons

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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