Key result
Severe sepsis in a critically ill 74-year-old male triggered reverse Takotsubo cardiomyopathy, which demonstrated echocardiographic recovery after 10 days despite the patient's eventual death.
Case Report (n=1)
Reverse Takotsubo cardiomyopathy can occur in critically ill patients secondary to severe sepsis, contributing to hemodynamic worsening, but may be reversible.
Supports potential reversibility of sepsis-associated reverse Takotsubo cardiomyopathy; leaves open questions on survival impact.
Takotsubo, or stress cardiomyopathy (SC), is described as a transient systolic dysfunction of the apical segments of the left ventricle mainly triggered by emotional or physical stress resembling the presentation of an acute coronary syndrome in the absence of obstructive coronary artery disease. Reverse Takotsubo SC is a rare variant of SC that presents with basal ballooning instead of apical ballooning seen in classic SC. We present a case of a 74-year-old male who was admitted to the ICU with septic shock. Laboratory test results showed elevated troponin. An echocardiogram showed reduced cardiac contractility and relative hypokinesis of the basal and mid segments compared to the apical segments, consistent with reverse Takotsubo SC, which recovered after 10 days. It can happen in critically ill patients in the ICU secondary to severe sepsis and could contribute to hemodynamic worsening, affecting the final clinical outcomes.
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Ghallab et al. (2023) conducted a case report in Reverse Takotsubo Cardiomyopathy (n=1). Severe sepsis was evaluated on Cardiac contractility and left ventricular ejection fraction. Severe sepsis in a critically ill 74-year-old male triggered reverse Takotsubo cardiomyopathy, which demonstrated echocardiographic recovery after 10 days despite the patient's eventual death.
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