Why the study?
Does IMD-0354 improve left ventricular remodeling and cardiac dysfunction in rats after myocardial infarction?
Does IMD-0354 improve left ventricular remodeling and cardiac dysfunction in rats after myocardial infarction?
Inhibition of NF-kappaB with IMD-0354 improves survival and attenuates adverse left ventricular remodeling and diastolic dysfunction in a rat model of myocardial infarction.
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May support NF-κB inhibition to limit post-MI remodeling in rats; leaves open translation to human therapy.
Onai et al. (2006) studied this question.
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