Why the study?
Does targeted disruption of the p50 subunit of NF-kappaB improve cardiac function and survival after myocardial infarction in mice?
Population
Male knockout mice with targeted disruption of the p50 subunit of NF-kappaB and age-matched wild-type mice…
Comparison
Targeted disruption of the p50 subunit of… vs Age-matched wild-type mice subjected to…
Design
Preclinical
Authors
Loading...
Should not yet change post-MI care; leaves open NF-kappaB blockade as a target to reduce rupture and improve remodeling in future studies.
Does targeted disruption of the p50 subunit of NF-kappaB improve cardiac function and survival after myocardial infarction in mice?
Targeted disruption of the p50 subunit of NF-kappaB reduces ventricular rupture and improves cardiac function and survival after myocardial infarction in a mouse model, suggesting a potential therapeutic target for post-MI remodeling.
Kawano et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: