March 11, 2005Cardiovascular Research

Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

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Why the study?

Does blockade of NF-kappaB activation improve cardiac function and survival in a mouse model of TNF-alpha-induced cardiomyopathy?

Population

Transgenic mice with cardiac-specific overexpression of TNF-alpha (model of cytokine-induced cardiomyopathy)

Comparison

Genetic disruption of the p50 subunit of… vs Transgenic mice with intact p50 subunit of…

Design

Preclinical

Authors

NKNatsumi KawamuraMayo Clinic TKT KUBOTAKyushu University SKShin KawanoResearch Organization of Information and Systems

Discussion

Member takes

Implication

p50 disruption benefits TNF-α cardiomyopathy mice via MMP-9; leaves open translation to human heart failure therapy.

Structured PICO

Does blockade of NF-kappaB activation improve cardiac function and survival in a mouse model of TNF-alpha-induced cardiomyopathy?

Population

Transgenic mice with cardiac-specific overexpression of TNF-alpha (model of cytokine-induced cardiomyopathy)

Intervention

Genetic disruption of the p50 subunit of NF-kappaB (TG/p50(-/-) mice)

Comparator

Transgenic mice with intact p50 subunit of NF-kappaB (TG/p50(+/+) mice)

Outcome

Cardiac function and survivalsurrogate

Blockade of NF-κB activation improves cardiac function and survival in a mouse model of TNF-α-induced cardiomyopathy by suppressing MMP-9, suggesting a potential therapeutic target for heart failure.

Cite This Study

Kawamura et al. (2005) studied this question.

synapsesocial.com/papers/6a7eb474481667ae799a162a https://doi.org/10.1016/j.cardiores.2005.02.007

Topics

Cardiomyopathy

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Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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