Why the study?
Digoxin is used in symptomatic chronic heart failure, but the relation between digoxin use and change in renal function over time was not well established.
Does digoxin use affect the rate of decline in renal function in patients with chronic heart failure?
Population
1241 patients with symptoms and signs of CHF
Comparison
Never on digoxin vs digoxin throughout vs started digoxin vs stopped digoxin
Design
Observational cohort study
Authors
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Digoxin use associated with faster eGFR decline in HF; hypothesis-generating, requires randomized confirmation before practice implications.
Does digoxin use affect the rate of decline in renal function in patients with chronic heart failure?
In patients with chronic heart failure, digoxin use is associated with a significantly faster rate of decline in renal function compared to those not taking digoxin.
Hanning et al. (2021) studied this question.