Why the study?
Is early-stage diabetic kidney disease coupled with Helicobacter pylori infection associated with increased carotid intima-media thickness in type 2 diabetic patients?
Is early-stage diabetic kidney disease coupled with Helicobacter pylori infection associated with increased carotid intima-media thickness in type 2 diabetic patients?
Early-stage DKD and H. pylori infection may synergistically increase atherosclerosis risk, as measured by CIMT, in type 2 diabetic patients.
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May suggest synergistic CIMT elevation in T2DM with early DKD plus H. pylori; hypothesis-generating, needs prospective validation.
Objective. This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods. A cross-sectional study including 180 type 2 diabetic participants was conducted to explore the associations between CIMT and early-stage DKD coupled with H. pylori infection, and a stepwise multivariate regression analysis evaluated the correlations of CIMT with clinical and serologic parameters. Results. The type 2 diabetic patients with early-stage DKD coupled with H. pylori infections had the highest CIMT values. Apolipoprotein B (ApoB), urine albumin/creatinine ratio (UACR), and interleukin-6 (IL-6) were independent predictors of CIMT. Conclusions. Early-stage DKD coupled with H. pylori infection may synergistically lead to significant CIMT thickening in type 2 diabetic patients. Additionally, ApoB, UACR, and IL-6 levels were important independent risk factors for increased CIMT.
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Feng et al. (2018) studied this question.
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