What question did this study set out to answer?

To evaluate cardiac hemodynamics, work demands, and left ventricular performance in patients with end-stage renal disease undergoing maintenance hemodialysis.

March 1, 1977Annals of Internal Medicine

Cardiac Work Demands and Left Ventricular Function in End-Stage Renal Disease

View Full Paper

Ask AI

Bookmark

Authors

JCJohn P. CapelliStevens Institute of Technology

Discussion

Member takes

Implication

Hemodynamic study demonstrates elevated cardiac work and ventricular filling pressures in hemodialysis patients, suggesting chronic overload and anemia induce heart failure.

Key Points

To evaluate cardiac hemodynamics, work demands, and left ventricular performance in patients with end-stage renal disease undergoing maintenance hemodialysis.
Conducted right and left heart catheterization in patients on hemodialysis (N=9).
Evaluated hemodynamics before and after temporary occlusion of arteriovenous communications, with post-mortem pathological assessment.
All patients exhibited elevated stroke work index, left ventricular work index, and left ventricular end-diastolic pressure, with markedly elevated pressure in 5 patients that remained unchanged upon arteriovenous occlusion.
Cardiac output was significantly elevated at baseline and normalized postocclusion, while indirect indices of myocardial oxygen consumption were increased.
Six patients died, including four from myocardial failure without infarction, and five showed increased cardiac weight at autopsy.

Cite This Study

John P. Capelli (1977) studied this question.

synapsesocial.com/papers/6a84b33d1505246ba71dd83e https://doi.org/10.7326/0003-4819-86-3-261

View Full Paper

Ask AI

Bookmark

Implication

Hemodynamic study demonstrates elevated cardiac work and ventricular filling pressures in hemodialysis patients, suggesting chronic overload and anemia induce heart failure.

Cardiac Work Demands and Left Ventricular Function in End-Stage Renal Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Cardiac Work Demands and Left Ventricular Function in End-Stage Renal Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider