Why the study?
While the angiotensin-II/AT1R axis has been extensively explored in inflammation, understanding the role of the AT2R in inflammation is an emerging research area.
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Design
Review
The angiotensin AT2 receptor is an emerging therapeutic target with potential anti-inflammatory and tissue-protective effects.
The hyperactive RAS and inflammation are closely associated. The angiotensin-II/AT1R axis of the RAS has been explored extensively for its role in inflammation and a plethora of pathological conditions. Understanding the role of AT2R in inflammation is an emerging area of research. The AT2R is expressed on a variety of immune and non-immune cells, which upon activation triggers the release of a host of cytokines and has multiple effects that coalesce to anti-inflammation and prevents maladaptive repair. The anti-inflammatory outcomes of AT2R activation are linked to its well-established signaling pathways involving formation of nitric oxide and activation of phosphatases. Collectively, these effects promote cell survival and tissue function. The consideration of AT2R as a therapeutic target requires further investigations.
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Patel et al. (2020) studied this question.
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