Plasma gangliosides from tumor-bearing mice undergo quantitative and qualitative changes and can enhance tumor growth when transferred.
Ganglioside changes may promote tumor growth in mice; hypothesis-generating and requires human validation before any clinical consideration.
Gangliosides in the plasma of Ehrlich ascites tumor-bearing mice showed changes, both quantitative and qualitative, with progress of tumor. Quantitative changes assessed by chemical estimation indicated a gradual increase of gangliosides up to day 6 of tumor growth followed by a decline leading to a level below the normal by day 12. Qualitative changes studied by thin-layer chromatography indicated appearance of new gangliosides in the plasma of tumor-bearing mice, which were absent from normal plasma. One of these gangliosides appears to be of tumor-cell origin. Gangliosides obtained from tumor-bearing mouse plasma enhanced tumor growth when adoptively transferred with tumor cells into normal mice.
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Saha et al. (1988) studied this question.
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