Why the study?
Does adoptive transfer of plasma gangliosides affect tumor growth in mice?
Does adoptive transfer of plasma gangliosides affect tumor growth in mice?
Total plasma gangliosides enhance Ehrlich ascites tumor growth in mice, an effect dependent on the complete mixture of its enhancing and inhibitory components.
Should not alter clinical cancer care; leaves open the role of ganglioside mixtures in human tumor progression.
Total plasma gangliosides of Ehrlich ascites tumor-bearing mice enhanced tumor growth when adoptively transferred with the same tumor cells in mice. However, individual gangliosides acted differently. Out of 6 gangliosides separated from plasma, 2 components enhanced tumor growth, whereas the remaining 4 inhibited tumor growth. Neither of the 2 enhancing components in various combinations with the 4 inhibitory components could restore the enhancing effect. The enhancing effect was restored only when both the enhancing components were mixed with the remaining 4 ganglioside components, i.e., with full/complete reconstitution.
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Saha et al. (1990) studied this question.
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